Pseudolymphoma cutaneous lymphoid hyperplasia is a benign. Krasnaliev3 1 department of dermatology and venereology, medical university varna. Report of two cases 111 the pcr of immunoglobulin heavy chain igh gene rearrangement showed polyclonality. Cutaneous pseudolymphomas can be separated into two major subtypes, pseudolymphomas mimicking a cutaneous b cell lymphoma b cell pseudolymphomas and pseudolymphomas mimicking a. Pilar gonzalezperamato, in urologic surgical pathology fourth edition, 2020. Polymorphous and top heavy infiltrate germinal centers make definitive diagnosis tingible body macrophages.
A case of borrelia associated cutaneous pseudolymphoma in a horse article in veterinary dermatology 232. If you are new to the forums, you must login or register a free account before you can post. The authors report on a case of pseudolymphoma cutis in a 48yearold man. Druginduced pseudolymphoma results from exposure to medications, which results in cutaneous inflammatory patterns that resemble lymphoma, most frequently mycosis fungoides 11930 see also.
Collections of epithelioid macrophages were present in both cases and were reminiscent of epithelioid granulomas. C is often the first clue of impending ahs, usually preceding the ap. Lymphocytoma cutis, also known as spieglerfendt sarcoid or pseudolymphoma, is a rare lesion, presenting either as localized solitary nodule or as disseminated multiple shiny plaques. Polymerase chain reaction analysis of tcell receptor gene. Disease bioinformatics research of cutaneous pseudolymphoma has been linked to pseudolymphoma, lymphoma, dermatologic disorders, skin neoplasms, hyperplasia. Jun 26, 2016 historical aspects cutaneous pseudolymphoma cpl was first described under the term sarcomatosis cutis by kaposi in 1891. It heals spontaneously after cessation of the causative factor e. A variety of specific diseases, such as actinic reticuloid, lymphomatoid contact dermatitis, pigmented purpuric dermatosis, and lymphomatoid drug. Clinicopathologic correlation is essential to achieve the final diagnosis in cutaneous psl and to differentiate it from cutaneous lymphomas. Cutaneous pseudolymphoma, lymphomatoid contact dermatitis type, as an unusual cause of.
A group of disorders having a benign course but exhibiting clinical and histological features suggestive of malignant lymphoma. A case of pseudolymphoma of the liver operated with. Pseudolymphoma cutaneous lymphoid hyperplasia is a benign inflammatory response that histologically and often clinically mimics cutaneous lymphoma. After complete excision of the whole lesion, there has been no recurrence during the followup period of 12 months. Pseudolymphoma, also known as jessners lymphocytic infiltration, is a benign but usually chronic, tcell infiltrating disease with erythematous papules and plaques usually seen on the skin of. Cutaneous pseudolymphoma cpsl is defined as reactive polyclonal benign lymphoproliferative process predominantly composed of either bcells or tcells, localized or disseminated. Treatment and cure for pseudolymphoma doctor answers on. Lamotrigineinduced cutaneous pseudolymphoma mdedge. Miliarial type pseudolymphoma mimicking as granulomatous rosacea.
It manifests with diarrhoea, hepatosplenomegaly, moderate lymph node enlargement without histopathological changes and evidence of the reticuloendothelial system involvement. Gharaei nejad kaveh 1, rafiei rana 1, azimi seyyede zeinab 1, rafiee behnam 2. Pseudolymphoma is a benign reactive process with a lymphoid cell proliferation so intense that it may be mistaken for lymphoma. Pseudolymphoma is not a specific disease but rather an inflammatory response to known or unknown stimuli that results in a lymphomatousappearing but benign accumulation of inflammatory cells. Tcell pseudolymphoma presenting in a lichenoid and. Pdf phenytoin induced cutaneous b cell pseudolymphoma. Pseudolymphoma, cutaneous lymphoid hyperplasia, reactive lymphoid hyperplasia, lymphocytoma cutis, spieglerfendt sarcoid, pseudolymphoma of spieglerfendt, lymphadenosis benigna cutis are all terms that describe lesions in which there is usually a dense proliferation of lymphocytes which is not malignant. In most situations, this appears to be a reactive process, though a number of dermatologic conditions can be difficult to distinguish from a lymphoma. Pseudolymphoma is a benign inflammatory response occasionally linked to an inciting antigen that simulates cutaneous lymphomas. Searching literature we could not find any previous reports of phenytoin. Pseudolymphoma bupropion diagnosis of pseudolymphoma download here free healthcaremagic app to ask a doctor. The patient was immunocompetent and free from hiv, hbv, hcv, htlv. Reevaluation using modern molecular biology techniques, epilepsia on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. In 1923, bilerstein coined term lymphocytoma cutis term lymphadenosis benigna cutis was introduced by bafverstedt in 1943 in 1967, lever introduced term pseudolymphoma of spiegler and fendt subsequently,caro and helwig in.
Hydantoininduced cutaneous pseudolymphoma with clinical, pathologic, and immunologic aspects of sezary syndrome. Pseudolymphoma definition of pseudolymphoma by medical. Both tcell and bcell forms of pseudolymphoma may be seen. Symptoms of pseudolymphoma doctor answers on healthcaremagic. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. Jun 14, 2014 tcell pseudolymphoma presenting in a lichenoid and nodular pattern. Historical aspects cutaneous pseudolymphomacpl was first described under the term sarcomatosis cutis by kaposi in 1891. Pseudolymphomas occur in a younger population, and have been associated with collagen diseases, systemic lupus erythematosus, sjogren syndrome. Phenytoin induced pseudolymphoma syndrome solanki b r.
In cutaneous pseudolymphoma, resemblance to lymphoma is usually most apparent histologically, but some examples may also mimic lymphoma clinically. It has been proposed that phenytoin induced pseudolymphoma syndrome may develop frank malignant lymphoma because there is an increased chance of a malignant clone developing at a time when the immunosurveillance system is impaired due to lymphadenopathy and a loss of tcell supressor function. Over the years, a wide variety of designations have been included in this category. Results from immunohistochemistry testing showed a mixed population of b and t cells. Based on these features, we diagnosed cutaneous lymphoid hyperplasia pseudolymphoma. Lymphoma and pseudolymphoma julie777s question cancer. Cutaneous pseudolymphoma fitzpatricks dermatology, 9e. You can now download visualdx for your ios and android devices. Download here free healthcaremagic app to ask a doctor all the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. Cutaneous pseudolymphoma christina mitteldorf, mda, werner kempf, mdb,c keywords cutaneous pseudolymphoma tcell bcell borreliosis tattoo histology key points cutaneous pseudolymphoma psls are a heterogeneous group of lymphocyterich infiltrates, simulating clinically andor histologically cutaneous lymphoma.
Liver and intrahepatic bile ducts tumor reactive lymphoid hyperplasia pseudolymphoma. The term cutaneous pseudolymphoma refers to a heterogeneous group of benign skin disorders that simulate cutaneous lymphomas histologically and sometimes clinically. It is a process that simulates a cutaneous lymphoma blood cell cancer developing in the skin, but it behaves in a harmless manner. Cutaneous pseudolymphomacpl was first described under the term sarcomatosis cutis by kaposi in 1891. Eckhauser, 2 and lee weatherbee 3 departments of 1radiology, 2 surgery, and 3 pathology, university of michigan and veterans administration medical center, ann arbor, michigan, usa abstract. A big problem for the clinicians is the differential diagnosis between cutaneous pseudolymphoma and malignant cutaneous lymphomas, as well as possibility for transformation of cutaneous pseudolymphoma into malignant lymphomas. These 2 groups correspond to druginduced pseudolymphoma and hypersensitivity syndrome. Pdf we report a case of pseudolymphoma of the liver in a 49yearold woman without an underlying disease except for liver hemangioma. The postoperative course was uneventful, she was discharged on pod 8. Tcell pseudolymphoma presenting in a lichenoid and nodular. Pseudolymphoma, also called as cutaneous lymphoid hyperplasia, is a skin lesion having lymphomatous appearance mimicking lymphoma that results from. What is cutaneous pseudolymphoma cutaneous pseudolymphoma refers to a group of conditions that simulate a lymphoma blood cell cancer, but behave in a harmless manner. No causative agents such as microbial, physical, chemical, insect bite.
We think that they are 2 distinct entities with different clinical and biological features and outcome, even if the pathological findings are sometimes similar. In 1923, bilerstein coined term lymphocytoma cutis term lymphadenosis benigna cutis was introduced by bafverstedt in 1943 in 1967, lever introduced term pseudolymphoma of spiegler and fendt subsequently,caro and helwig in 196. Krasnaliev3 1 department of dermatology and venereology, medical university varna 2 department of dermatology and venereology, medical university sofia. However, sensitized patients with a history of ahs may present within 1 day of resuming therapy with an aromatic anticonvulsant. Information and translations of pseudolymphoma in the most comprehensive dictionary definitions resource on the web.
Pseudolymphoma is characterized by dense lymphoid infiltrates of the skin, which may be focal or diffuse. The study of cutaneous pseudolymphoma has been mentioned in research publications which can be found using our bioinformatics tool below. The benign behavior of certain lymphoprolifera tive disorders involving the alimentary tract has been recognized for many years 1 3. Some of these represent outdated synonyms, some refer to variants of the same entity, and some are misnomers for diseases now recognized to be true lymphomas. Druginduced pseudolymphoma and hypersensitivity syndrome. Pseudolymphomas may arise in response to a wide variety of foreign antigens, but most are idiopathic. All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. Pseudolymphoma causes doctor answers on healthcaremagic. Aug 14, 2019 pseudolymphoma is not a specific disease but rather an inflammatory response to known or unknown stimuli that results in a lymphomatousappearing but benign accumulation of inflammatory cells. Cutaneous pseudolymphoma is a term used to describe a heterogeneous group of benign reactive t cell, bcell or mixed cell type lymphoproliferative processes that resemble cutaneous lymphomas clinically andor histopathologically. Cutaneous pseudolymphoma refers to a heterogenous group of benign reactive tcell or bcell lymphoproliferative processes of diverse causes that simulate cutaneous lymphomas clinically and histologically. Based on these histological features, the lesion was diagnosed as pseudolymphoma of the liver. In 1923, bilerstein coined term lymphocytoma cutis term lymphadenosis benigna cutis was introduced by bafverstedt in 1943 in 1967, lever introduced term pseudolymphoma of spiegler and fendt subsequently,caro and helwig in 1969 introduced term.
Cutaneous pseudolymphoma is a term used to describe skin lesions that bear a clinical andor histopathologic resemblance to lymphoma. We experienced a case of pseudolymphoma of the liver which was operated after 15 years follow up. Lymphoma cutis is the most important type of pseudolymphoma. I was then told theres a strong connection between the 2 but wonder why i wasnt warned about this when i. The term, cutaneous pseudolymphoma psl, refers to a group of lymphocyterich infiltrates, which either clinically andor histologically simulate cutaneous lymphomas. Lymphocytoma cutis is a rare pseudolymphoma that has also been known as cutaneous lymphoid hyperplasia or lymphadenosis benigna cutis. Histologically, cutaneous t cell pseudolymphomas may show a superficial bandlike pattern simulating early patchplaquestage mycosis fungoides mf or a nodular or diffuse pattern simulating peripheral t cell lymphoma, not otherwise specified ptcl, nos or tumorstage mf. Pseudolymphoma is a benign lymphocytic infiltrate that resembles cutaneous lymphoma histologically, clinically, or both. Pseudolymphoma is characterized by a benign infiltration of lymphoid cells or histiocytes which microscopically resembles a malignant lymphoma.
A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Cutaneous pseudolymphoma cpl was first described under the term sarcomatosis cutis by kaposi in 1891. Cutaneous lymphoid hyperplasia refers to a groups of benign cutaneous disorders characterized by collections of lymphocytes, macrophages, and dendritic cells in the skin 725 conditions included in this groups are 725 cutaneous lymphoid hyperplasia with nodular pattern, a condition of the skin characterized by a solitary or localized cluster of asymptomatic erythematous to violaceous. A big problem for the clinicians is the differential diagnosis between cutaneous pseudolymphoma and malignant cutaneous lymphomas, as well as possibility for.
Jul 21, 2015 lymphocytoma cutis, also known as spieglerfendt sarcoid or pseudolymphoma, is a rare lesion, presenting either as localized solitary nodule or as disseminated multiple shiny plaques. Cutaneous pseudolymphoma is considered to be a benign reactive cutaneous lymphoid infiltrate. Cutaneous lymphoid hyperplasia pseudolymphoma cmaj. Cutaneous pseudolymphomas actas dermosifiliograficas. I was then told theres a strong connection between the 2 but wonder why i wasnt warned about this when i got the psuedolymphoma diagnosis. Lymphoma and pseudolymphoma was anyone else diagnosed with pseodolymphoma prior to the actual lymphoma diagnosis. A case of borrelia associated cutaneous pseudolymphoma in a. University of texas, md anderson cancer center 1515 holcombe blvd. It is a pseudolympoma of blymphocytes affecting young adults with a female predilection 3. Polymerase chain reaction analysis of tcell receptor gene rearrangement revealed a peak at 228 bp in a predominantly polyclonal background. A case of borrelia associated cutaneous pseudolymphoma in.
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